NEERI2010 is the second Networking Event of its kind, providing a follow-up to NEERI2009 held in Helsinki. The goal of NEERI2010 is to exchange ideas on a number of topics relevant for research infrastructures and to clear common ground on the further development and application of these topics. NEERI focuses on what we share and what we can learn from each other. Examples of such commonalities are architectural issues, communication with users and integration of services and tools.NEERI will focus more on general aspects of research infrastructure development across all disciplines, including the natural and life sciences.