The new AGRIS initiative, which was launched at the Expert Consultation in October 2005, has defined three main areas of intervention to improve international information systems in agricultural science and technology: Advocacy, Capacity Building and Content Management. Content management, the management of agricultural science and technology information, has various needs: standards and methodologies for interoperability and facilitation of knowledge exchange; tools to enable information management specialists to process data; information and knowledge. This paper describes some of the efforts that have been made in this area over recent years.